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Pain Unit

The Pain Unit at FMUP is headed by the Full Professor Deolinda Lima, comprises several subgroups and is also affiliated to the Institute for Molecular and Cell Biology (IBMC) of University of Porto. The Group has a long track of publications since the 70's, studying the neurobiological mechanisms of pain, and is one leading group in Portugal and Europe in the field, being very competitive at the national and international level. Although the entire team is focused on the Physiopathology of Pain and works together sharing know-how and technical training, the group is organized in several sub-units, each one with different expertise, dedicated to particular aspects of pain and supervised by a senior investigator. Their research activities range from the anatomo-physiology of pain circuits to molecular and circuit pain-induced changes and cognitive-emotional impairment.

Specifically, researchers at the Group have been involved in the:
  1. molecular characterization of DRG and spinal cord neurons physiologically or under pain conditions, in embryonic and adult stages (immunohistochemistry and molecular biology techniques);
  2. electrophysiological characterization of the spinal pain processing circuit;
  3. identification of plastic changes in the neurotransmitters systems supraspinally and study of the endogenous pain control system (in situ hybridization and immunohistochemistry, behavioural pharmacology);
  4. identification of signalling pathways (c-Fos, ERKs, neurotrophins) altered under chronic pain;
  5. characterization of cognitive-emotional impairment during chronic pain (behaviour and multi-electrode electrophysiology);
  6. development of therapies for visceral pain and associated pathologies at the urogenital system;
  7. evaluation of the efficacy of gene therapy manipulation of the endogenous pain control system;
  8. epidemiology of pain in Portugal.

To attain its objectives the group brings together various expertise and facilities that are frequently combined to answer scientific questions in each sub-area. These include:
  1. Molecular Biology and biochemistry (RT-PCR, cloning, cell culture, radioactive and non-radioactive in situ hybridisation, Western and southern blotting, ELISA, ...);
  2. Tissue and neuronal circuitry histology and histochemistry;
  3. Advanced microscopy (with up-to-date and high quality light, fluorescent-confocal and apotome microscopes, electron microscopy, image acquisition and analysis software);
  4. Microsurgery, stereotaxic and intrathecal canulation, neuronal tracing;
  5. Classic and multielectrode in vivo electrophysiology;
  6. Patch clamp electrophysiology;
  7. Nociceptive and cognitive animal behavior;
  8. Epidemiological Studies;
  9. Computational neuroscience (in cooperation)

The Group publishes yearly several papers in peer-reviewed international journals (see PubMed for Institute of Histology and Embryology, University of Porto, or Instituto de Histologia e Embriologia, Faculdade de Medicina, Universidade do Porto) and collaborations are maintained with regular mobilities/visits and trainings in prominent laboratories, mainly in Europe and USA, while a strong involvement in outreach activities is accomplished through multiple national and international programs.

The team includes people from different backgrounds (pharmacy, biology, biochemistry, nutrition, etc), with medical doctors amounting to 20% of the team.

The Group has a long record of supervising researchers from the undergraduate up to the Post Doc level being highly involved in pre and post-graduation training activities, with organization of courses, seminars and workshops. The Pain Research Group or some of its members have been engaged in the organization of several important national and international scientific meetings in the neurosciences and especially in the pain field (e.g. FENS2004, IASP Congress 2008, EFIC Congress 2009).

At the national level, the members of the Group are actively engaged in organizing and lecturing several post-graduation courses which are part of PhD studies Programs, including the Doctoral Program in Neuroscience. At the European Community level, the Group is also involved in organizing and/or participating in several EFIC Pain Schools as well as in PENS Schools. At present there are several PhD students, and on average two/three PhD students get their degree per year. All PhD theses in the group include 4 to 6 papers published or in press. Several master students defend their thesis with work doen at the Unit. There are also several young research grantees (assistant researchers) and several pre-graduation students doing research work every year in the laboratory.

Activity Report 2009

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Publications January 2006 - September 2010

Books and Book Chapters

  • Neto, F.L., Ferreira-Gomes, J. and Castro-Lopes, J.M. (2006) Distribution of GABA receptors in the thalamus and their involvement in nociception. In: GABA (Ed. S.J. Enna). Advances in Pharmacology vol. 54, pp-29-51
  • Castro-Lopes, J.M. (2007) Fisiopatología del dolor neuropático. In: Tratado de dolor neuropático (J. Serra Catafau Ed.), Editorial Médica Panamericana, Madrid, pp. 115-127
  • Cruz, F. New therapeutic targets in BPH and LUTS. Research priorities. K-E Andersson, F Cruz, H Klocker, M Wyllie, O Yamaguchi. Em: International Consultation on BPH (2005) (Editores C Chatelin, L Denis, K.T. Foo, S Khoury e J McConnell). WHO. 2007.
  • Galhardo, V. (2007) Thalamus, Dynamics of Nociception. In: Encyclopedia of Pain. Schmidt, R.F. & Willis, W.D., editors, pp. 2444-2446, Springer-Verlag, New York
  • Lima, D. (2007) Ascending Pathways: Anatomy and Physiology. In: The Senses: A Comprehensive Reference. Basbaum, A. et al., editors, pp. 477-526, Elsevier, London
  • Lima, D. (2007) Spinothalamic Tract Neurons, Morphology. In: Encyclopedia of Pain. Schmidt, R.F. & Willis, W.D., editors, pp. 2282-2285, Springer-Verlag, New York
  • Oliveira-Maia, A.J., Simon, S.A., & Nicolelis, M.A.L. (2007) Neural ensemble recordings from central gustatory-reward pathways in wake and behaving animals. In: Methods for Neural Ensemble Recordings, 2nd Edition. Nicolelis, M.A.L., editor, CRC Press, Boca Raton
  • Castro Lopes, J.M., Raja, S. and Schmelz, M. (Eds) Pain (2008) An updated review. J.M. IASP Press, Seattle
  • Lima, D. (2008) Ascending pathways: anatomy and physiology. In: Science of Pain; Allan Basbaum, Catherine M. Bushnel, editors. Elsevier
  • Oliveira-Maia, AJ, Simon, SA, Nicolelis, M.A.L. (2008) Gustation. In: Encyclopedia of Neuroscience; Binder, M.D., Hirokawa N, Windhorst U, (Eds). Springer-Verlag, New York.
  • Castro Lopes JM (Ed.), Current Topics in Pain. (2009) 12th World Congress on Pain. IASP Press, Seattle
  • Charrua A., Avelino A., Silva A., Cruz F. (2010) TRPV1 in GU disorders. The Open Drug Discovery. 2, 50-54

Review Papers & Editorials

  • Almeida, A., Leite-Almeida, H. and Tavares, I.(2006) Medullary Control of Nociceptive Inputs: Reciprocal Communications with the Spinal Cord. Drug Discovery Today, 3 (3): 305-312 (7.152)
  • Avelino, A and Cruz, F. (2006) TRPV1 (vanilloid receptor) in the urinary tract. Expression, function and clinical applications. Naunym-Schmiedeberg's Archives 373:287-99 (2.631)
  • Cruz, F. and Silva, C. (2006) Refractory neurogenic detrusor overactivity. International Journal of Clinical Practice, 60: 22-26 (1.188)
  • Szallasi, A., Cruz, F. and Geppetti, P. (2006) TRPV1: a therapeutic target for novel analgesic drugs? Trends Mol. Med. 12:545-54 (5.864)
  • Beubler, E., Eisenberg, E., Castro-Lopes, J., Rhodin, A. (2007) Prescribing policies of opioids for chronic pain. Journal of Pain & Palliative Care Pharmacotherapy, 21: 53-55
  • Cruz, F. (2007) Editorial Comment on: Effect of thalamic deep brain stimulation on lower urinary tract function. Eur. Urol., 53: 612 (4.85)
  • Cruz, F. (2007) Urinary urgency is brought to the receptor level. Editorial comment. Neurourol Urodyn, 26:439 (2.671)
  • Cruz, F., Dinis, P. (2007) Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms. Neurourology and Urodynamics, 26: 920-927 (2.68)
  • Cruz, F., Silva, C. (2007) Treatment of overactive bladder. European Renal & Genito-Urinary Disease ISSUE II
  • Tavares, I., Lima, D. (2007) From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system. J. Anat., 211: 261-268 (2.46)
  • Cruz, F. (2008) Editorial Comment. European Urology,53:607-612 (6.512)
  • Andersson KE, Chapple CR, Cardozo L, Cruz F, Hashim H, Michel MC, Tannenbaum C, Wein AJ (2009) Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opinion Urol 19: 380-394 (2.619)
  • Heinricher MM, Tavares I, Leith JL, Lumb BM (2009) Descending control of nociception: specificity, recruitment and plasticity. Brain Res Rev 60: 214-25 (6.236)
  • Neugebauer V, Galhardo V, Maione S, Mackey SC (2009) Forebrain Pain Mechanisms. Brain Res Rev 60: 226-242 (6.236)
  • Seixas D, Basto M.A (2009) Neuroimaging: just a collection of brain image files? Frontiers of Human Neuroscience 11; 3:47
  • Silva CM, Cruz F (2009) Has botulinum toxin therapy come of age: what do we know, what do we need to know, and should we use it? Curr Opin Urol 19:347-52 (2.619)
  • Birder LA, Kanai AJ, Cruz F, Moore K, Fry CH (2010) Is the urothelium intelligent? Neurourol Urodyn 29:598-602 (2.693)
  • Cruz F., Desgrandchamps F. (2010) New Concepts and Pathophysiology of Lower Urinary Tract Symptoms in Men. Eur. Urol. Suppl., 9:472-476 (7.667)

Original Papers

  • Araújo, I.E., Gutierrez, R., Oliveira-Maia, A.J., Pereira Jr, A., Nicolelis, M.A,L. and Simon, S.A. (2006) Neural ensemble coding of satiety states. Neuron, 51: 483-494 (13.894)
  • Castro, A.R., Morgado, C., Lima, D. and Tavares, I. (2006) Differential expression of NK1 and GABAB receptors in spinal neurons projecting to antinociceptive or pronociceptive medullary centers. Brain Res Bull 69: 266-275 (1.684)
  • Castro, A.R., Pinto, M., Lima, D. and Tavares, I. (2006) Secondary hyperalgesia in the monoarthritic rat is mediated by GABBAB and NK1 receptors of spinal dorsal horn neurons: A behavior and c-fos study. Neuroscience 141: 2087-2095 (3.427)
  • Cruz, C.D., McMahon, S.B. and Cruz, F. (2006) Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats. Exp. Neurol. 200:66-73 (4.156)
  • Dickson, A., Avelino, A., Cruz, F. and Ribeiro-da-Silva, A. (2006) Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide induced cystitis. Neuroscience 139:671-685 (3.427)
  • Ferreira-Gomes, J., Neto, F.L. and Castro-Lopes, J.M.(2006) GABAB(2) receptor subunit mRNA decreases in the thalamus of monoarthritic animals. Brain Res. Bull. 71(1-3):252-258 (1.684)
  • Monteiro, C., Lima, D. and Galhardo, V. (2006) Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons. Neuroscience Letters 398(3):258-63 (2.092)
  • Morato, M., Pinho, D., Sousa, T., Tavares, I. and Albino-Teixeira, A. (2006) Inhibition of nociceptive responses of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal medulla oblongata. J. Neurosci. Res. 83:647-655 (3.476)
  • Pinho, D., Sousa, T., Morato, M., Tavares, I. and Albino-Teixeira, A. (2006) Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats. Brain Res. 1073-1074:374-82 (2.341)
  • Pinto, M., Lima, D. and Tavares, I. (2006) Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: involvement of spino-medullary and intra-medullary connections. Neurosci. Lett. 409:100-105 (2.092)
  • Potes, C.S., Neto, F.L. and Castro-Lopes, J.M. (2006) Administration of baclofen, a GABAB agonist, in the thalamic ventrobasal complex attenuates allodynia in monoarthritic rats subjected to the ankle-bend test. J Neurosci Res 83:515-523 (3.476)
  • Potes, C.S., Neto, F.L. and Castro-Lopes, J.M. (2006) Inhibition of pain behaviour by GABAB receptors in the thalamic ventrobasal complex: effet on normal rats subjected to the formalin test of nociception. Brain Res., 1115: 37-47 (2.341)
  • Rebelo, S., Chen, Z.F., Anderson, D.J. and Lima, D. (2006) Involvement of DRG11 in the development of the primary afferent nociceptive system. Mol. Cell. Neurosci. 33: 236-246 (4.607)
  • Aguiar, P., Mendonça, L., Galhardo V. (2007) OpenControl: a free opensource software for video tracking and automated control of behavioral mazes. Journal of Neuroscience Methods, 166: 66-72 (2.24)
  • Baiou, D., Santha, P., Avelino, A., Charrua, A., Bacskai, T., Matesz, K., Cruz, F., Nagy, I. (2007) Neurochemical characterization of insulin receptor- expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice. Journal of Comparative Neurology, 503: 334-347 (3.83)
  • Charrua, A., Cruz, C., Cruz, F., Avelino, A. (2007) Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis. The Journal of Urology, 177: 1537-1541 (3.95)
  • Cruz, C., Ferreira, D., McMahon, S., Cruz, F. (2007) The activation of the ERK pathway contributes to the spinal c-fos expression observed after noxious bladder stimulation. Somatosensory and Motor Research, 24: 15-20 (0.63)
  • Cruz, C.D., Cruz, F. (2007) The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction. Curr. Neuropharmacol., 5: 244-252 (0.98)
  • Ferreira, J.G., Cruz, C.D., Neves, D. and Pignatelli, D. (2007) Increased ERK phosphorylation in the adrenal gland in response to chronic ACTH treatment. J Endocrinol, 192:647-658 (2.636)
  • Morgado, C., Tavares, I. (2007) C-fos expression at the spinal dorsal horn of streptozotocin-induced diabetic rats. Diabetes Metab. Res. Rev., 23: 644-652 (2.55)
  • Pais-Vieira, M., Lima, D., Galhardo, V. (2007) Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats. Neuroscience, 145: 225-231 (3.42)
  • Pinto, M., Lima, D., Tavares, I. (2007) Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: a c-fos study in acute and chronic articular inflammation. Neuroscience, 147: 1076-1089 (3.42)
  • Rebelo, S., Reguenga, C., Osório, L., Pereira, C., Lopes, C., Lima, D. (2007) DRG11 immunohistochemical expression during embryonic development in the mouse. Dev. Dyn., 236: 2653-2660 (3.16)
  • Safronov, B.V., Pinto, V., Derkach, V.A. (2007) High-resolution single-cell imaging for functional studies in the whole brain and spinal cord and thick tissue blocks using light-emitting diode illumination. J. Neurosci Methods, 164: 292-298 (2.24)
  • Santos, S., Rebelo, S., Derkach, V., Safronov, B. (2007) Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat. J. Physiol., 581: 241-254 (4.41)
  • Silva, C., Silva, J., Castro, H., Reis, F., Dinis, P., Avelino, A., Cruz, F. (2007) Bladder sensory desensitization decreases urinary urgency. BMC Urology, 7: 9 (5.634)
  • Silva, J., Silva, C., Saraiva, L., Silva, A., Pinto, R., Dinis, P., Cruz, F. (2007) Intraprostatic botulinum toxin type A injection in patients unfit for surgery presenting with refractory urinary retention and benign prostatic enlargement. Effect on prostate volume and micturition resumption. Eur. Urol., 53: 153-159 (4.85)
  • Araujo I E, Oliveira-Maia, A J, Sotnikova, T, Gainetdinov, R, Caron, M, Nicolelis, M, Simon, S (2008) Food reward in the absence of taste receptor signaling. Neuron 57: 930-941 (14.170)
  • Charrua A, Reguenga C, Paule C, Nagy I, Cruz F, Avelino A (2008). Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia. Neuroreport 19:1469-72 (1.904)
  • Cruz CD, Charrua A, Vieira E, Valente J, Avelino A, Cruz F (2008). Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals. Exp. Neurol. 214: 301-308 (3.974)
  • Ferreira-Gomes J, Adães S, Castro-Lopes JM (2008). Assessment of movement-evoked pain in osteoarthritis by the knee-bend and CatWalk tests: a clinically relevant study. J. Pain 9:945-954 (3.387)
  • Martins I. Pinto M, Wilson S P, Lima D, Tavares I (2008). Dynamic of migration of HSV-1 from a medullary proonociceptive centre: antinociception by overexpression of the preproenkephalin transgene. Eur. J. Neurosc. 28:2075-2083 (3.385)
  • Morgado C, Pinto-Ribeiro F, Tavares I (2008). Diabetes affects the expression of GABA and potassium chloride cotransporter in the spinal cord: a study in streptozotocin diabetic rats. Neurosci. Lett. 438:102-106 (2.200)
  • Morlion B, Walch H, Yihune G, Vielvoye-Kerkmeer A, de Jong Z, Castro-Lopes JM, Stanton-Hicks M (2008). The Pain Associates' International Network Initiative: a novel practical approach to the challenge of chronic pain management in Europe. Pain Pract. 8:473-480
  • Neto FL, Carvalhosa A, Ferreira-Gomes J, Reguenga C, Castro-Lopes J.M. (2008). Delta opioid receptor mRNA expression is changed in the thalamus and brainstem of monoarthritic rats. J. Chem. Neuroanat. 36:122-127 (2.580)
  • Pinto M, Castro, A R., Tshudy, F, Wilson, S, Lima, D, Tavares I (2008). Opioids modulate pain facilitation from the dorsal reticular nucleus. Mol. Cell. Neurosci. 39:508-518 (3.934)
  • Pinto M, Sousa M, Lima D, Tavares I. (2008). Expression of µ-opioid, GABAB and NK1 receptors in spinally-projecting neurons of the caudal medulla oblongata: implications for descending modulation of nociceptive transmission. J. Comp. Neurol. 510:175-187 (3.743)
  • Pinto V, Derkach VA, Safronov BV (2008). Role of TTX-sensitive and TTX-resistant sodium channels in A?- and C-fiber conduction and synaptic transmission. J. Neurophysiol. 99: 617-628 (3.648)
  • Pinto V, Szûcs P, Derkach V, Safronov B (2008). Monosynaptic convergence of C- and A&-afferent fibres from different segmental dorsal roots on to single substantia gelatinosa neurons in the rat spinal cord. J. Physiol. 586.17: 4165-4177 (4.649)
  • Pozza DH, Fregapani PW, Weber JBB, Oliveira MG, Oliveira MAM, Ribeiro Neto N, Macedo Sobrinho JB. Analgesic action of laser therapy (LLLT) in an animal model (2008). Med. Oral Patol. Oral Cir. Bucal, 13:E648-52
  • Seixas D, Ayres Basto M (2008). Ethics in fMRI studies: a review of the EMBASE and MEDLINE literature. Clin. Neuroradiol. 18:79-87
  • Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, Turner E, Lima D, Ma Q. (2008) Tlx1 and Tlx3 Coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J. Neurosci. 28: 4037-4046 (7.452)
  • Charrua A, Cruz CD, Narayanan S, Gharat L, Gullapalli S, Cruz F, Avelino A (2009) GRC 6211 a new oral specific TRPV1 antagonist reduces bladder overactivity and noxious bladder input in cystitis animal models J Urol 181: 379-386 (3.952)
  • Charrua A, Reguenga C, Cordeiro JM, Correia de-Sa P, Paule C, Nagy I, Cruz F, Avelino A (2009) Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells. J Urol 182: 2944-2950 (3.952)
  • Ferreira SG, Lomaglio T, Avelino A, Cruz F, Oliveira CR, Cunha R A, Kofalvi A (2009) Naclydopamines control striatal input terminals via novel ligand-gated cation channels. Neuropharmacology 56: 676-683 (3.382)
  • Guimarães M, Oliveira R, Pinto R, Soares A, Maia E, Botelho F, Sousa T, Pina F, Dinis P, Cruz F. (2009). Intermediate-term results, up to 4 years, of a bone-anchored male perineal sling for treating male stress urinary incontinence after prostate surgery: BJU Int. 2009 103(4):500-504 (2.865)
  • Marques-Lopes J, Pinto M, Pinho D, Morato M, Patinha D, Albino-Teixeira A, Tavares I (2009) Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. Neuroscience 158: 1301-1310 (3.556)
  • Oliveira R, Silva A, Pinto R, Silva J, Silva C, Guimarães M, Dinis P, Cruz F (2009) Short-term assessment of a tension-free vaginal tape for treating female stress urinary incontinence. BJU Int Epub 2009 (2.704)
  • Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan T, Mummalaneni S, Melone P, DeSimone JÁ, Nicolelis MAL, Simon S A (2009) Nicotine activates TRPM5-dependent and independent taste pathways. PNAS, 106: 1596-1601 (9.380)
  • Pais-Vieira M, Mendes-Pinto M, Lima D, Galhardo V (2009) Cognitive impairment of prefrontal-dependent decision-making in a rat model of chronic pain. Neuroscience 161: 671-679 (3.556)
  • Pais-Vieira M., Lima D, Galhardo V (2009) Sustained attention deficits in rats with chronic inflammatory pain. Neuroscience Letters 463: 98-102 (2.200)
  • Rebelo S, Lopes C, Lima D, Reguenga C (2009) Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system. Int J Dev Biol, 53: 1089-1095 (2.359)
  • Rodrigues LG, Ferraz MJ, Rodrigues D, Pais-Vieira M, Lima D, Brady RO, Sousa MM, Sá-Miranda MC (2009) Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice. Neurobiology of Disease 33, 48-56 (4.852)
  • Santos SF, Luz LL, Szucs P, Lima D, Derkach V, Safronov BV (2009) Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PlosOne 30(4): e8047 (4.351)
  • Silva J, Pinto R, Carvalho T, Botelho F, Silva P, Oliveira R, Silva C, Cruz F, Dinis P. (2009). Intraprostatic Botulinum Toxin Type A injection in patients with benign prostatic enlargement: duration of the effect of a single treatment. BMC Urol. 15;9:9
  • Silva J, Pinto R, Carvalho T, Coelho A, Avelino A, Dinis P, Cruz F (2009) Mechanisms of prostate atrophy after glandular botulinum neurotoxin type A injection: an experimental study in the rat. Eur Urol 56: 134-140 (6.512)
  • Szucs P, Pinto V, Safronov BV (2009) Advanced technique of infrared LED imaging of unstained cells and intracellular structures in isolated spinal cord, brainstem, ganglia and cerebellum. J Neurosci Methods 177: 369-380 (2.295)
  • Botelho F, Pina F, Silva P, Figueiredo G, Cruz F, Lunet N. Vascular endothelial growth factor (VEGF) and prostate pathology. Int Braz J Urol. 2010 36:430-7 (4.016)
  • Coelho A., Dinis P., Pinto R., Gorgal T., Silva C., Silva A., Silva J., Cruz CD., Cruz F., Avelino A. (2010) Distribution of the High-Affinity Binding Site and Intracellular Target of Botulinum Toxin Type A in the Human Bladder EUROPEAN UROLOGY, 57:884-890 (7.667)
  • Ferreira-Gomes J, Adães S, Sarkander J, Castro-Lopes JM (2010) Phenotypic alterations of neurons that innervate osteoarthritic joints. Arthritis & Rheumatism, in press (DOI 10.1002/art.27713) (7,332)
  • Ji G, Sun H, Fu Y, Li Z, Pais-Vieira M, Galhardo V and Neugebauer V (2010) Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation The Journal of Neuroscience, 30: 5451-5464 (7.178)
  • Marques-Lopes J, Pinho D, Albino-Teixeira A, Tavares I (2010) The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine 5 noradrenergic cell group. Brain Res., 1325:41-52. (2.551)
  • Martins I, Araújo S, Fadel J, Wilson SP, Lima D, Tavares I (2010) Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain. Pain (in press) (6.125)
  • Monteiro C, Rebelo S, Galhardo V, Reguenga C and Lima D (2010) Postnatal expression of the homeobox gene Prrxl1 (Drg11) is increased in inflammatory but not neuropathic pain. Eur. J. Pain (in press) (3,37)
  • Morgado, M, Pereira-Terra P, Tavares I (2010) Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin. Eur. J. Pain, 14:693-699 (4.019)
  • Neto FL, Borges G, Torres-Sánchez S, Mico JA and Berrocoso E (2010) Neurotrophins Role in Depression Neurobiology: a Review of Basic and Clinical Evidence. Curr. Neuropharmacol. Special issue (in press) (0.8)
  • Pinho D, Morato M,Couto MR, Marques-Lopes J, Tavares I, Albino-Teixeira A (2010) Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems? Pain modulation in the hypertensive-monoarthritic rat. J. Pain (in press) (4.219)
  • Pinto R,Frias B,Allen S,Dawbarn D,McMahon SB,Cruz F,Cruz CD (2010) Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. Neuroscience. 166:907-16. Epub 2010 (3.292)
  • Pinto R,Lopes T,Frias B,Silva A,Silva JA,Silva CM,Cruz C,Cruz F,Dinis P (2010) Trigonal injection of botulinum toxin a in patients with refractory bladder pain syndrome/interstitial cystitis. Eur Urol. 58:360-5. Epub 2010 (6.327)
  • Pinto V, Szucs P, Lima D and Safronov BV (2010) Multisegmental A?- and C-fiber input to neurons in lamina I and the lateral spinal nucleus. Journal of Neuroscience 30: 2384-2395 (7.18)
  • Pozza DH, Potes CS, Cardoso P, Azevedo LF, Castro-Lopes JM e Neto FL (2010) Modulation of the nociceptive behaviour by mu-opioid receptors in the ventrobasal complex of the thalamus of rats. Pain 148: 492-502. Epub 2010 Jan 27 (6.125)
  • Rebelo S, Reguenga C, Lopes C, Lima D (2010) Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons. Dev Dyn. 239:1684-94 (3,08)
  • Silva A, Cardoso-Cruz H, Silva F, Galhardo V, Antunes L (2010) Comparison of Anesthetic Depth Indexes Based on Thalamocortical Local Field Potentials in Rats. Anesthesiology 112:355- 63 (5.354)
  • Szucs P, Luz LL, Lima D and Safronov BV (2010) Local axon collaterals of lamina I projection neurons in the spinal cord of young rat. Journal of Comparative Neurology 518: 2645-2665. (3.72)
  • Tomada N, Tomada I, Cruz F, Vendeira P, Neves D (2010) Characterization of VEGF and angiopoietins expression in human corpus cavernosum during aging. J Sex Med. 7:1410-8. Epub 2010 (4.884)

EAC 2010 - Morphophysiology SS - Group Structure

Group Structure
Pain Unit Cell Division Group Stress and Ageing Group Translational Neuro-Urology Group
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